Corrigendum: Translating the observed differences in interleukin-6 levels between some antiretroviral regimens into potential long-term risk of serious non-AIDS events: A modeling study

[This corrects the article DOI: 10.3389/fimmu.2022.976564.].

In the published article, there was an error in Tables 2 and 3 and Figures 1 and 2 as published. A formula correction was implemented in the.xlsm file containing the Markov model, leading to changes to the previously reported results. The corrected Tables 2 and 3 and Figures 1 and 2 and their captions appear below.
Corrections have also been made to the Abstract, Results, Paragraph 1. This paragraph previously stated: "Over 144 weeks, PWH on one of the three-drug regimens studied were predicted to spend 22% more time in the low IL-6 quartile and 13% less time in the high IL-6 quartile compared with those on one of the two-drug regimens. Over 144 weeks, the predicted mean number of SNAEs/deaths per 100 PWH was 5.6 for a three-drug regimen associated with lower IL-6 levels versus 6.8 for a two-drug regimen associated with higher IL-6 levels. The number needed to treat for one additional SNAE/death among PWH receiving a two-drug versus three-drug regimen for 240 weeks was 43. Approximately 2,900 participants would be required for a 240-week clinical study to evaluate the accuracy of the model." The corrected paragraph appears below: "Over 3 years, PWH on one of the three-drug regimens studied were predicted to spend 13% more time in the low IL-6 quartile and 11% less time in the high IL-6 quartile compared with those on one of the two-drug regimens. Over 3 years, the predicted mean number of SNAEs/deaths per 100 PWH was 6.58 for a three-drug regimen associated with lower IL-6 levels versus 6.90 for a two-drug regimen associated with higher IL-6 levels. The number needed to treat for one additional SNAE/death among PWH receiving a two-drug versus three-drug regimen for 3 years was 81. Approximately 7,500 participants would be required for a 5-year clinical study to evaluate the accuracy of the model." A correction has been made to the Results, IL-6 trajectories from the Markov model, Paragraph 1. This sentence previously stated: "Within a time horizon of 144 weeks, PWH maintained on the three-drug ART regimens that were associated with lower IL6 levels ('lower IL-6' regimen) were predicted to spend 22% more  Average time spent in each IL-6 quartile according to ART regimen at (A) 3 years and (B) 5 years, according to the model, which used the IL-6 trajectories seen in TANGO (n=741, up to Week 144) and AIR (n=148, Weeks 144-240).
time in the low IL-6 quartile and 13% less time in the high IL-6 quartile than those switching to a two-drug ART regimen associated with higher IL-6 levels ('higher IL-6' regimen) ( Figure 1A)." The corrected sentence appears below: "Within a time horizon of 3 years, PWH maintained on the three-drug ART regimens that were associated with lower IL6 levels ('lower IL-6' regimen) were predicted to spend 13% more time in the low IL-6 quartile and 11% less time in the high IL-6 quartile than those switching to a two-drug ART regimen associated with higher IL-6 levels ('higher IL-6' regimen) ( Figure 1A)." Corrections have been made to the Results, Model-predicted SNAE/death rates and NNT, Paragraph 2.
(1) This sentence previously stated: "When all four IL-6 quartiles were combined, the predicted mean number of SNAEs/deaths per 100 PWH was 5.6 for continuous treatment with lower IL-6 compared with 6.8 with higher IL-6 ( Figure 2)." The corrected sentence appears below: "When all four IL-6 quartiles were combined, the predicted mean number of SNAEs/deaths per 100 PWH was 6.58 for continuous treatment with lower IL-6 compared with 6.90 with higher IL-6 ( Figure 2)." (2) This sentence previously stated: "Results for the 240-week timeframe based on adding the 148 AIR study participants followed the same pattern, and the predicted mean numbers of SNAEs/ deaths per 100 PWH were 11.9 and 15.8 for the three-and two-drug regimens, respectively." The corrected sentence appears below: "Results for the 5-year timeframe based on adding the 148 AIR study participants followed the same pattern, and the predicted mean numbers of SNAEs/deaths per 100 PWH were 14.87 and 17.49 for the three-and two-drug regimens, respectively." (3) This sentence previously stated: "Based on these results, we calculated that for every 43 PWH treated for 240 weeks after switching to the two-drug regimen, there could be one additional SNAE/death as a consequence of higher IL-6, based on the association of IL-6 values and clinical outcomes from the INSIGHT studies." The corrected sentence appears below: "Based on these results, we calculated that for every 81 PWH treated for 5 years after switching to the two-drug regimen, there could be one additional SNAE/death as a consequence of higher IL-6, based on the association of IL-6 values and clinical outcomes from the INSIGHT studies." Corrections have been made to the Results, Clinical trial size required to validate model-predicted results, Paragraph 1.
(1) This sentence previously stated: "On this basis, 2,906 participants would be required for a study with a 240-week treatment period. Variations in the sample size according to the study duration are shown in Table 3." The corrected sentence appears below: "On this basis, 7,591 participants would be required for a study with a 5-year treatment period. Variations in the sample size according to the study duration are shown in Table 3." (2) This sentence previously stated: "For example, a total of almost 10,000 patients would be needed for a 240-week study with a threeversus two-drug regimen ratio of 2:1." The corrected sentence appears below: "For example, a total of almost 8,500 patients would be needed for a 5-year study with a three-versus two-drug regimen ratio of 2:1." The authors apologize for these errors and state that they do not change the scientific conclusions of the article in any way. The original article has been updated. Incidence of serious non-AIDS events (cardiovascular, hepatic or renal event, or malignancy) or all-cause death according to IL-6 quartile and ART regimen over (A) 3 years and (B) 5 years, according to the model, which used the IL-6 trajectories seen in TANGO (n=741, up to Week 144) and AIR (n=148, Weeks 144-240).

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